(MO) MERCILON DESOGESTREL ETHINYLOESTRADIOL .150/.020 MG 21 TABS RX

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Mercilon is an oral contraceptive for women. The active ingredients: Desogestrel and Ethinylestradiol.

Pharmacodynamics

One of the active substances of Mercilon tabs, Desogestrel, has a concentration effect, which is achieved mainly by inhibiting ovulation and also increases the viscosity of cervical mucus. The use of Desogestrel reduces the level of estradiol in the liquid part of the blood to a level that corresponds to the early follicular phase. It does not affect carbohydrate and lipid metabolism and changes in the biological system that ensures the maintenance of normal blood viscosity. After entering the body, it is quickly absorbed into the chemical Etonogestrel, the bioequivalence of which is reached in the blood after about 2 hours. It binds more to blood proteins and less to globulin, which impacts sex hormone binding.

Another active ingredient of Mercilon is Ethinyl Estradiol, which also has a rapid and absolute absorption effect, whose bioequivalence in blood fluid is reached within 2 hours. Complete absorption of the substance during presystemic metabolism is about 60%. This active substance has a strong binding effect with serum albumin and increases the increase in serum concentration of sex hormone binding. The distribution of Ethinylestradiol takes place in the mucosa of the small intestine and in the liver. The level of presence of this substance in the liquid part of the blood decreases during the day. It is excreted from the body in an altered form with urine and bile.

The combination of these two active substances in Mercilon tablets increases the effectiveness of the drug

Pharmacological action

Mercilon has a contraceptive effect based on the interaction of various factors, such as reduction of pain during menstruation, reduction of premenstrual syndromes, protects against pregnancy.

There is also evidence that Mercilon, can reduce the risk of tumors in the female reproductive organs and mammary glands, as well as reduce the development of iron deficiency anemia during heavy menstruation.

Although Mercilon is quite effective in inhibiting ovulation, if abdominal pain occurs, a diagnosis should be made to rule out an ectopic pregnancy. In patients who tend to disturb the formation of melanin pigment in the direction of increasing, it is necessary to avoid direct sunlight and not to use a solarium during the use of the drug.

It should also be considered that the use of any hormonal contraceptives may affect the effectiveness of other drugs. Because of this, the concentration of the liquid part of the blood and tissues may both increase and decrease. When prescribing this medication, the prescriber should discuss the possibility of various complications with each individual patient and determine the likelihood of risk versus benefit of the medication. If the patient decides to take the drug, it should be monitored regularly and in case of deterioration consider its discontinuation.

What does Mercilon using for?

Mercilon should be taken on the first day of menstruation, one tablet a day, at the same time, for 21 days. The sequence of intake is indicated on the package. Mercilon should be taken without crushing, with water if necessary. After 21 days of taking Mercilon, take a one-week break. During this seven-day interval, a menstrual-like reaction occurs, which may be less abundant than usual and longer. Menstruation usually occurs on the 2nd or 3rd day after the 21-day course. After a one-week break, you should restart taking a new pack of Mercilon. You may also start taking Mercilon tablets immediately after a pregnancy termination in the first trimester. If you miss taking the tablets, you can use the following recommendations:

Week 1

Week 2

Week 3

Take the last missed pill immediately after mentioning the omission, in which case 2 pills are taken at the same time, after which the normal intake is resumed according to the scheme, and in addition, you should use protective measures such as a condom. Remember, the more you skip, the greater the risk of pregnancy.

If you miss taking the pill in the second week, you should immediately take two pills at once, and then resume taking the regular regimen. If in the first week the pill was taken strictly according to its scheme, no additional protection is required.

If you break the schedule frequently, there is an increased risk of falls protection against pregnancy, in which case you should use additional barrier protection, such as a contraceptive cap or condom.

Side effects of Mercilon

  • Soreness, increase, appearance of mammary gland secretion
  • Vaginal discharge
  • Change of appetite
  • Sleeplessness or lethargy
  • Increased body temperature
  • Migraine pains
  • dullness
  • Nausea, vomiting
  • Menstrual disorders
  • Change of body weight
  • Swelling
  • Change in blood composition
  • Change of libido
  • Increase in blood viscosity

Contraindications

  • Diabetes mellitus accompanied by vascular complications
  • Tumors and severe liver diseases
  • Hypersensitivity to Medicinal components
  • In acute or chronic inflammation of the pancreas
  • Unspecified vaginal blood discharges
  • Lupus erythematosus
  • Increased blood pressure
  • Cardiac patients who have had heart problems
  • Pregnant or nursing women

Use with caution in cases of obesity, smoking after 35 years of age, unspecified vaginal bleeding, possible pregnancy, cystic lesions, lupus erythematosus, the tendency to pigmentation, ulcers, or colitis.

Overdose

No significant adverse effects have been observed in overdose of Mercilon. In rare cases, there may be a feeling of loss of reality and, in younger patients, a slight bloody discharge from the vagina. In case of overdose, suitable support measures should be applied to the body in the hospital.

Rules of storage

Store Mercilon in a dry place where it will not be exposed to strong heat, moisture or direct sunlight at 2-25 °C. Limit access of children to the drug.

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