Anapsique (Amitriptyline, Elavil)

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Amitriptyline generic is an antidepressant medication with the main active ingredient Amitriptyline. Amitriptyline medication has been developed for the first time in “Merck Sharp & Dohme” company laboratory in 1960 and in 1961 it was approved for use in the USA, and in 1962 in Italy and England.

The recommended use of Amitriptyline generic is for diagnosed severe depressive conditions of various forms of manifestation. 


Amitriptyline is rapidly absorbed after administration. The bioavailability of the active substance is about 30-60%. AB is maximally, almost 96% bound to blood proteins and is maximally concentrated within 2-7 hours. Of the main characteristics, high permeability through the blood-brain barrier and the central nervous system, as well as through the placental barrier into breast milk can be noted. The active substance is mainly metabolized in the liver and excreted with urine for 31-46 hours. 

Clinical Pharmacology

Amitriptyline medication has a high antidepressant effect. The mechanism of action of the drug is to relieve depressive states, and to normalize the work of the brain.

In a depressed patient, Amitriptyline (Elavil) improves mood, reduces or relieves melancholy, lethargy, apathy, anxiety, restlessness, irritability, and emotional tension. It increases mental activity, normalizes the phase structure and duration of sleep, and normalizes appetite. The medication is used for various forms of schizophrenia, bulimia, which has a nervous nature, migraine, to relieve pain, diabetic neuropathy, and nocturnal enuresis in children.

The drug may also be used to treat peptic ulcer disease, gastroesophageal reflux disease, heartburn, and dyspepsia. Amitriptyline generic is a broad-spectrum drug with high efficacy. Compared to other antidepressants, Amitriptyline has a good therapeutic effect at a low price.  


Amitriptyline (Elavil) is used for various forms of depression, especially if the patient additionally has anxiety or increased excitability. The doctor may also prescribe the drug for sleep disorders, depression resulting from brain damage, as well as depression resulting from the side effects of other drugs. It is also prescribed for pain arising in patients with malignant tumors.

Amitriptyline is started with a low dose, gradually increasing to the dose recommended by the doctor. Depending on the form of the disease, Amitriptyline 25mg is taken three times a day, gradually increasing the dosage, but not more than 150 mg per day. Exceeding the dose of 150 mg, if there is a need, is carried out in the hospital under the supervision of specialists. Amitriptyline25mg and Amitriptyline 50mg are used for comfort use. 

Amitriptyline: Side Effects

Amitriptyline medication is generally well tolerated by most patients, but various side effects may occur

  • High blood pressure
  • Nausea
  • Upset stomach
  • Headache
  • Sleepiness
  • Dizziness
  • Tremors of the hands
  • Arrhythmia, tachycardia
  • Pupil dilation decreased visual acuity
  • Discomfort, violation of sensitivity
  • Allergic reactions
  • Darkening of the tongue
  • Heartburn
  • Jaundice
  • Intestinal obstruction
  • Reduced or increased appetite
  • Enlarged salivary glands
  • General weakness
  • Memory impairment
  • Aggressiveness
  • Convulsions
  • Decreased libido, potency
  • Increased or decreased blood sugar levels
  • Changes in blood tests

While taking Amitriptyline (Elavil) you may have a higher sedative effect, increased dryness of the mouth, and constipation. 


If there is hypersensitivity to the drug, during the rehabilitation period after a heart attack, in heart rhythm disorders, during breastfeeding or pregnancy, or during alcohol poisoning Amitriptyline is not prescribed. 

Recommendations for use

Amitriptyline (Elavil) should be taken with caution if there are signs of depression with suicidal tendencies, as well as delayed urination, thyroid dysfunction, prostate, severe liver disease, heart disease, diabetes with complications, and patients with rare hereditary diseases.

Amitriptyline has the ability to affect the reaction rate, so you need to be extremely careful when driving vehicles or working with any mechanisms. It is desirable to avoid driving motor transport during the treatment.

If it is necessary to increase the dose of Amitriptyline above 150 mg per day, you should go to a hospital for monitoring by specialists. 


Symptoms of Amitriptyline 25mg and Amitriptyline 50mg overdose may occur unnoticed and slowly, or in some cases abruptly and suddenly. Seizures, dry mucous membranes, fever, sudden suppression of the nervous system, reduction of consciousness to a state of coma and with breath-holding are possible. Different cardiac blockages with cardiac arrest. There may also be confusion, anxious agitation, and hallucinations. 

Sharp drop in blood pressure

If you overdose on Amitriptyline, you must be admitted to a hospital urgently, where symptomatic and supportive treatment will be prescribed. 

Interaction with other medications

Amitriptyline should not be taken concomitantly with drugs that inhibit or delay physiological and physicochemical processes.

Amitriptyline should not be used in combination with the following drugs:

  1. Drugs aimed at lowering blood pressure, because they may reduce their effectiveness
  2. Antiarrhythmic, antipsychotic drugs due to the possibility of increased arrhythmias
  3. Antifungal drugs, because they cause increased concentrations in the blood serum, which may lead to associated toxicity
  4. Due to the simultaneous use of Amitriptyline with depressants, the sedative effect of alcohol and other central nervous system depressants may increase

Storage rules

Store Amitriptyline in a dry place, where the drug will not be exposed to strong heat, moisture or direct sunlight at a temperature not exceeding 25 °C. Limit access of children to the drug.

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Shipping & Returns

 we are a Registered and Licensed Mexican pharmacy we assure you top quality medicines without the worry of your health care provider, employer or any other group finding out what rightfully is a private issue.

Did you know that your private medical file can be used against you to raise your insurance rates or in some cases and countries to lose your job? We take your privacy very seriously and by using these payment methods and the way in which we use them your bank does not directly get charged from our pharmacy. This way your medical needs stay as private as possible.

You will also receive a complete invoice in your email with payment totals and simple payment instructions toward the bottom of the email should you wish to pay at a later convenience.

IMPORTANT: If you need to make some changes in regards an existing order, contact us within 24 hours, otherwise, Medicines Mexico is not liable due to errors on customer’s information or products presentation. 


Shipping Methods.

To ensure the delivery of your order we handle EXPRESS SHIPPING only. Signature is required.
Tracking numbers for all orders will be sent with instructions once shipped.


How long does it take to ship the drugs to my home or office?

  • Express USA time frame: 10-21 business days.   ($24.95 USD Signature required)
  • Express World Wide time frame: 15-30 business days.  ($39.95 USD Signature required)


*Due to unexpected Postal Service changes, one of the shipping methods above could be temporarily disabled.

IMPORTANT: Please ensure your mail program is configured to accept email from sender, add our email to your non blocked email address so we may send invoices, order status and shipping confirmations. If you do not receive your invoice immediately after this, please check your spam filter and make necessary changes. 

We reply promptly to your enquiries and requests emails, but are too busy to repeatedly resend email that customers do not receive because our replies have been moved to a customers’ Spam, Junk or Bulk email folder.

Online pharmacy Medicines Mexico shipping terms and conditions.
Our team endeavors to process all orders and ship within 72 business hours. All credit card and electronic check payments for your mexicanrxpharm take 24 to 48 hours to be approved by our Payment Processor; upon verification your order will be processed. If there are any problems with your order, we will contact you, so please ensure the email address and phone number you provide is correct, and that any spam filtering software you use accepts email from

Express Shipping.
We offer Mex Post Express Shipping as an option. This option costs from $24.95 depending on the quantity of medications in your order (up to 9 medications). This option requires a customer signature on delivery. For all other locations Express Shipping is $39.95. All packages are shipped in plain packaging to guarantee your privacy. All packages are sent by parcel express mail from Mexico. Some parcels require a signature upon delivery at our discretion. There are no other handling fees, drug dispensing fees, or Mexican customs charges. If two or more people are ordering their prescription drugs from the same address at the same time, you will be billed for only one shipping charge from our Mexico pharmacy, up to our maximum order quantities limited by customs to 90 day supply. We are able to provide a tracking number on your express shipping parcels. If after 30 business days your order has not arrived, first check with your local postal office to ensure that your package is not being held for pick-up. If you still have problems, please contact us by email and we will attempt to assist you.

Notice Left
If no one is at home at the time of delivery, the status of you order on the Postal System will be updated to “Notice Left” which means USPS attempted to deliver your item and a notice was left because an authorized recipient was not available. You may arrange redelivery by visiting or calling 800-ASK-USPS, or may pick up the item at the Post Office indicated on the notice. If this item is unclaimed after five days then it will be returned to the sender. You can pay for reshipping $24.95 in order to receive a new tracking number. (Reshipping will be issued until the package is received back in our offices).

Note that on Holidays season, the Mexican Postal, USA and other countries will be extra busy; therefore a delay is expected in packages shipped during this season. You will need to consider as well the Mexican holidays. We appreciate your understanding, our customer service will be happy to assist you and available to inform you the latest status on your existing order shipped, you can always contact us at Toll Free number or email address.

Order Cancellation
Due to our policy of same day payment processing, ORDERS CANNOT BE CANCELLED.

Due to government regulations and the possibility of tampering with medications, returns cannot be accepted. In case your package is returned due to no one was available to sign for it. You can pay for reshipping $24.95 in order to receive a new tracking number. (Reshipping will be issued until the package is received back in our offices).

How to find the online pharmacy drug you need.
There are many more medications available in Mexico that are not listed on our website. If you can’t find the Mexican drug or medication you require, please contact us and we may be able to help. Some products are listed only in a single dosage size or medicine type, but may be available in other dosages and forms. Our experienced Mexican pharmacy Pharmacists will do their best to accommodate your requirements. Please always specify the chemical name of the medication (and any applicable brand name) with all inquiries. Please feel free to ask about ANY drug. We will reply promptly to your request.

What you should know about brand and generic drug alternates.
Prescription drugs are a costly medical expense, especially for the elderly, those who are chronically ill and those with no or minimal drug coverage on their Health Insurance. However, each state in America has a law that allows pharmacists to substitute less expensive generic drugs for many brand name products. Depending on your prescription needs, your savings could be very significant. Before you talk with your doctor or pharmacist about switching, there are things you should know about generic drugs.

What is the difference between a generic and brand name drug?
Nothing except for the name, packaging, and the price, a generic drug is called by its chemical name; manufacturers assign their own brand name. The generic products have the same ingredients. Standard practice and most state laws require that a generic drug be generically equivalent to its brand name counterpart. That is, it must have the same active ingredients, strength, and dosage form, be it a pill, liquid, or injection. The generic drug also must be therapeutically equivalent. It must be the same drug chemically and have the same medical effect.

Do all drugs have generic equivalents?
No. Some drugs are protected by patents and are supplied by only one company. However, when the patent expires, other manufacturers can produce its generic version. Currently, about half the drugs on the market are available in generic form.

Will my doctor automatically prescribe generic drugs?
It depends on the physician. You can ask your doctor to write a prescription permitting substitution of a generic drug product when appropriate or to define the chemical name for the prescription. This will ensure you are purchasing the correct Mexico drug. Generic products will be as effective and less costly. Or, you can order only brand name products if you wish. Mexico pharmacy offers a wide selection of both Brand Name & Generic Mexico medicine. Our Mexican generic drugs are of the highest quality, selected only from the most reputable manufacturers, and are safe to replace brand name medications costing much more.



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