Vortioxetine is prescribed for the therapy of serious depressive disorders in adult patients. Its effect on the body and improvement of the condition is made possible by inhibiting serotonin transfer proteins. It has antidepressant and anxiolytic properties. It improves cognitive functions, memory, and learning ability.
Vortioxetine hydrobromide showed maximum plasma concentration after 7-11 hours. The effectiveness of the drug increases in proportion to the dose. 5-20 mg of the active substance copes with a wide range of depressive and anxiety states. After the withdrawal of the drug, the risk of relapse is minimal.
Vortioxetine (Trintellix) can be taken by elderly patients. Studies have been able to obtain tolerability data in both adult patients. The drug has been shown to be effective in treating patients with severe depression and severe anxiety. The drug is suitable for the treatment of patients with a severe response to therapy. Vortioxetine generic in a dose of 10-20 mg was more effective than agomelatine in a dose of 25-50 mg.
Improvement of cognitive function was due more to the direct effect on cognitive processes than to the indirect effect through reduction of depressive state manifestations. The active substance improves the quality of life and general health. The effect of the drug persists after withdrawal.
The drug is well tolerated in short-term and long-term treatment. The drug has no effect on the quality of sleep, reduces the risk of insomnia, somnolence. The drug has no pronounced withdrawal symptoms during long-term treatment of 24-64 weeks or short-term use of 6-12 weeks. The drug does not affect changes in weight, heart rate, blood pressure. The half-life of the drug is 66 hours. Stable concentration is reached after 2 weeks.
Vortioxetine does not cause weight gain.
During the first few weeks, it’s necessary to monitor the patient's condition because of the risk of suicidal thoughts and health hazards. It’s especially important to monitor the condition of patients who have a history of suicide attempts. The drug is prescribed with caution in patients with a history of seizures. Antidepressants increase the risk of seizures. Use the drug with caution to treat patients with mania. In rare cases, the drug may cause serotonin syndrome or neuroleptic malignant syndrome. The risk of such a condition increases when concomitantly taken with serotonergic agents.
Vortioxetine (Trintellix) can be taken with or without food. Treatment of depressive and anxious states begins with 10 mg. After a few weeks of use, it is possible to change the dosage depending on tolerance. If the drug is well-tolerated, an increase to 20 mg per day is possible. The minimum dosage is 5 mg. When there is a decrease in the manifestations of depression and anxiety, treatment is continued for another 6 months to strengthen the therapeutic effect and eliminate the risk of relapse.
Treatment with Vortioxetine 10 mg can be abruptly withdrawn due to the absence of the risk of withdrawal syndrome. There is no need to adjust the dosage in elderly patients. When CYP2D6 inhibitors are added to the treatment regimen, the dosage of the antidepressant can be reduced. There is no data on the effects on children, so it’s not used for this age group.
The drug is characterized by moderate minimal manifestations of adverse reactions, which most often appear in the first two weeks of therapy and do not lead to withdrawal of the drug.
Vortioxetine Hydrobromide may cause the following reactions:
There are no data on an overdose of the drug. When taking a dose greater than the recommended one, the manifestation of adverse reactions increases. Such a condition is treated symptomatically.
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