Colchicine: instructions for use 

Colchicine is a substance of alkaloid nature, which significantly reduces the movement of leukocytes to the focus of the inflammatory process. This inhibits the uptake of microcrystalline parts of uric acid by phagocytes. 

Colchicine, which affects uric acid metabolism, is produced on a plant basis. The active ingredient of the same name in the remedy is isolated from the great flintless. This herbaceous plant has long been used in folk medicine to reduce joint pain and prevent the progression of inflammation.

The medicine is produced in tablet form. Tablets are mostly white, but sometimes have a slightly yellowish tinge. Round biconvex tablets have a risk, which simplifies compliance with the prescribed dosage. 

The drug has analgesic and anti-inflammatory effects. After taking it, it is possible to quickly stop an acute attack of gout. In addition, the active ingredient delays the deposition of uric acid microcrystals in the tissues. 

Colchicine Generic is able to significantly inhibit cell division, stops miosis, stops degranulation processes in neutrophils. 

The drug stops the development of amyloidosis and reduces the intensity of formation of amyloid structure fibrils. Colchicine tablets are highly effective in terms of stopping and preventing gout attacks of an acute nature. The therapeutic effect develops during the first day of use (in 75% of patients).

Indications for use

Colchicine is prescribed for:

1. In the treatment of gout. This disease is characterized by acute joint pain on the background of impaired uric acid metabolism and urate deposition in tissues. The remedy is shown to relieve pain at exacerbation of the disease and to slow its progression.

2. Amyloidosis, when a complex protein-polysaccharide compound - amyloid - is deposited in the tissues. This leads to malfunction of almost all systems and organs in the body.

3. Inflammatory diseases in otorhinolaryngology and dentistry.

4. Mediterranean fever, which is a hereditary disease associated with amyloid deposition in tissues. The main symptom is recurrent sudden increase in body temperature and severe chills.

5. Phlebitis. In this case, there is inflammation of the venous wall on the background of pathologies of infectious and inflammatory nature.

6. Scleroderma. The disease is characterized by the appearance of scar tissue on the skin and internal organs.

7. Chondrocalcinosis. When this pathology occurs, calcium pyrophosphate crystals are deposited in the articular cartilage and sac, causing painful sensations.

Treatment is prescribed by a doctor, so Colchicine over the counter is not dispensed. If you do not have time to make an appointment with a doctor, and treatment cannot be interrupted, you can buy Colchicine otc, as the doctor who works for the pharmacy will write a prescription for you. 

Foods to avoid when taking Colchicine

A diet low in purines can not only prevent the symptoms of diseases associated with elevated levels of uric acid in the blood but also improve overall health and well-being.

Purines are organic compounds that are part of nucleic acids and other important biologically active substances. In the human body, the end product of purine metabolism is uric acid. Disorders of purine metabolism can lead to increased levels of uric acid in the blood - hyperuricemia.

A diet low in purines can not only prevent the symptoms of diseases associated with elevated levels of uric acid in the blood but also improve overall health and well-being.

Gout patients should avoid excessive intake of alcoholic beverages, especially beer. Moderate consumption of wine is not associated with gout exacerbation. Excessive alcohol consumption leads to more frequent gout relapses, even with allopurinol therapy.

Patients should avoid drinks sweetened with high fructose syrup. It is also important to limit natural sweet fruit juices, table sugar, sugary drinks and desserts, and table salt. Grapefruit and grapefruit juice should be avoided when treated with Colchicine.

Foods containing high levels of purines include:

• red meat and game;
• certain seafood including: tuna, sardines, anchovies, herring, mussels, cod, scallops, trout, and haddock;
• meat by-products (kidney, liver, heart, etc.)
• legumes (peas, lentils, etc.).

It is recommended that these foods be significantly limited or avoided:

1. High-fat foods.
2. Alcohol. Beer and whiskey are particularly high in purines. Alcohol also causes dehydration, which makes it difficult for the body to eliminate uric acid.
3. Sweetened beverages: Fructose is an ingredient in many sweetened beverages, including fruit juices and carbonated drinks, and its excessive consumption is accompanied by a risk of developing gout.

Maintaining a high level of hydration by drinking plenty of fluids can be helpful in preventing gout recurrence. Since the association of gout with the development of atherosclerosis is well known, a diet low in cholesterol and fat is advisable.

Meals for gout should be fractional, the number of meals a day - from 4 to 6, portions of small volume. It is strongly not recommended to use salt in gout, if there is no way to abandon it, its quantity should be reduced. The basis of the diet in gout is lean fish and meat, which are cooked in boiled or baked form, vegetables and fruits. It is obligatory to consume dairy products every day.

Weight loss in obese patients can reduce uric acid levels. However, diets that cause ketosis (such as starvation) should be avoided.

How to take Colchicine for acute gout?

There is a regimen for taking to relieve acute pain. To do this, a whole tablet is taken. Then you take another 0.5-1 tablets at an interval of 60-120 minutes. The treatment is continued until the pain syndrome is relieved. The maximum allowable dose is 8 tablets per day.

How to use the drug?

It starts with a single dose, which is 1 mg. Then the drug is taken 0.5 mg every 3 hours until the intensity of painful signs is reduced. The total allowable amount of the drug in 1 course is 6 mg, exceeding the maximum dosage is strictly forbidden. The repeated course of treatment can be carried out not earlier than after 3 days. Reception for the prevention of relapses is 0.5 mg 2 to 3 times a day.

Elderly patients, people with kidney and liver diseases may need to reduce the dose or reduce the frequency of administration of the drug. The duration of the therapeutic course is determined by the doctor depending on the severity and intensity of symptoms, but most often it is short with high doses of the drug and frequent administration.

When to take Colchicine?

It is important to follow the doctor's recommendations. Most often, the drug is prescribed in the evening.

How long does it take for Colchicine to work?

Colchicine is rapidly and intensively absorbed from the gastrointestinal tract. The average maximum plasma concentration is 4.2 ng/ml and is reached approximately 70 minutes after a dose of 1 mg.

How long does Colchicine stay in your system?

The elimination half-life is 9.3 hours.

Why does Colchicine cause diarrhea?

The reason Colchicine causes diarrhea is to damage the mucosa of the small and large intestines. 

What are the side effects of Colchicine?

Colchicine use may be accompanied by: 

• malabsorption syndrome;
• peripheral neuritis;
• nausea;
• crust-like rash;
• neuropathy;
• azoospermia;
• renal dysfunction;
• vomiting;
• leukopenia;
• myelosuppression;
• diarrhea;
• urticaria;
• depression;
• thrombocytopenia;
• anorexia;
• myopathy;
• aplastic anemia;
• epigastric pain;
• neutropenia;
• alopecia of a temporary nature;
• liver dysfunction;
• agranulocytosis.

 Before Colchicine buy, consult your physician and read the instructions for the drug.

Contraindications

Colchicine is not prescribed in:

• hepatic insufficiency of an acute nature;
• bone marrow dysfunction;
• serious gastrointestinal disorders;
• neutropenia;
• indications in gerontological patients;
• renal failure of an acute nature;
• alcoholism;
• serious diseases of the myocardial and vascular system;
• infections of a purulent nature;
• indications in pregnant women;
• hypersensitivity reactions to colchicine and its analogues. 

The drug is prescribed only by a physician, self-treatment can only aggravate the disease.

Pregnancy

Prescribing is possible only under strict medical supervision in the absence of a safer alternative and in the presence of clear indications. The benefits of using the therapeutic agent must outweigh the possible high risks to the fetus. 

What happens if you take too much Colchicine?

Exceeding the therapeutic doses of the drug is accompanied by: 

• diarrhea of a severe nature;
• hematuria;
• hemorrhagic gastroenteritis;
• oral pain;
• hypotension;
• seizures;
• bouts of vomiting;
• pulmonary infiltrates;
• burning of the skin;
• epigastric pain;
• severe dehydration;
• altered myocardial function with ST-segment elevation;
• bouts of nausea;
• oliguria;
• respiratory depression;
• acute renal failure;
• hypovolemic shock;
• decreased myocardial contractility;
• hepatocellular damage;
• ascending paralysis. 

The patient should be treated in a toxicology inpatient unit. Hemodialysis in colchicine overdose is not used due to ineffectiveness. There is no specific antidote to colchicine. 

Colchicine drug interactions

It is important to tell your doctor what drugs you are taking besides Colchicine because some of them are incompatible. Examples are shown in the table below. 

Pharmacological group	Possible result of interaction with Colchicine
Sympathomimetics	Sympathomimetic potentiation
Cyanocobalamin	Impairment of absorption of cyanocobalamin
NSAIDS	Increased likelihood of thrombocytopenia, decreased white blood cell count
Cyclosporine	Risk of myopathic changes
Cytostatics	Decrease of Colchicine effectiveness
Drugs that alkalize the urine	Potentiation of the effects of Colchicine

 To buy generic Colchicine online, go to the website of our online pharmacy. You can buy Colchicine online from the comfort of your home, patients are always available the price of the drug and information about availability. 

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