Esbelcaps Fenproporex and Diazepam 20/6 mg 30 Caps

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Esbelcaps (Fenproporex and Diazepam 20/6) are specialized tablets crafted for weight management. They have shown commendable outcomes in battling obesity, a prevailing health issue in modern society. Prior to its consumption, it's imperative to consult with a medical professional to ascertain the correct method of application and the appropriate dosage for an individual's specific needs.

Brand and Composition Details

  • Brand Name: Esbelcaps.
  • Generic Components: Fenproporex and Diazepam.
  • Composition per Capsule:

Fenproporex: 20 mg

Diazepam: 6 mg

Detailed Information on the Ingredients

  • Diazepam: Recognized as a tranquilizing medication, Diazepam belongs to the benzodiazepine group. Notably, Diazepam augments the impact of Fenproporex, amplifying its effectiveness.
  • Fenproporex (Also known as Perphoxene): This compound, a stimulant derivative of amphetamine, functions as an appetite suppressant, specifically tailored for obesity treatment. Once consumed, Fenproporex is efficiently absorbed by the gastrointestinal tract. It achieves its initial plasma concentration within 30 minutes post-consumption, peaking after an hour. The steady state is maintained for about 6 hours. Notably, it gets expelled from the body through urine, transformed into active metabolites. On the other hand, Diazepam's absorption is rapid, hitting its peak concentration in an hour. It has a half-life of 15 days and gets eliminated in the urine either as active (oxides) or inactive (glycoconjugates) metabolites.

Indications and Usage

Esbelcaps is primarily designed as a weight management solution. It's most effective when complemented with a low-calorie diet regimen. Its primary role is to support those struggling with obesity.

Mechanism of Action

Fenproporex (Perphoxene)

  • Type: An amphetamine derivative stimulant.
  • Function: Acts primarily as an appetite suppressant, making it effective in the treatment of obesity.
  • Absorption & Metabolism: Fenproporex is well absorbed in the gastrointestinal tract. Its initial plasma concentration is achieved about 30 minutes post-administration (Vmax), reaching its peak after 60 minutes (Cmax). The drug maintains a stable state for approximately 6 hours (Tmax) and is excreted in the urine as active metabolites.


  • Type: A benzodiazepine sedative.
  • Function: Enhances the action of Fenproporex and provides anxiolytic, muscle relaxant, anticonvulsant, and sedative effects.
  • Absorption & Metabolism: Diazepam is quickly absorbed in the gastrointestinal tract, reaching a maximum concentration within one hour (Cmax). It has a half-life of approximately 15 days and is excreted in the urine in forms of active (oxides) or inactive (glycoconjugates) metabolites.

Possible Side Effects

Before embarking on a course of Esbelcaps, familiarize yourself with potential side effects:

  • Skin: Manifestations might include skin redness or paleness.
  • Cardiovascular System: Individuals might experience heart palpitations, irregular heart rhythms, angina pectoris-like chest discomfort, and fluctuations in blood pressure.
  • Gastrointestinal System: Symptoms could range from cramps, colic, diarrhoea, and constipation to nausea, vomiting, a parched mouth, and increased thirst.
  • Additional Symptoms: These could encompass dizziness, persistent headaches, vertigo, urinary retention, and an unusual metallic taste.


Esbelcaps might not be suitable for everyone. It's discouraged for those with:

  • Prostate hypertrophy
  • Glaucoma
  • Severe urinary or gastrointestinal tract diseases
  • Anorexia or chronic insomnia
  • Psychological disorders
  • Liver or renal malfunction
  • Minors (below 18)
  • Expecting mothers or those breastfeeding

Always consult with a physician before introducing Esbelcaps into your regimen.

Administration and Dosage

Consume the capsules orally. The recommended dosage is one capsule, taken 30 minutes prior to your first meal of the day.


Interactions between medications can lead to altered pharmacokinetic properties, diminished efficacy, or increased side effects. Here are potential interactions of Esbelcaps (Fenproporex and Diazepam 20/6 mg) with other medicines:

Monoamine Oxidase Inhibitors (MAOIs):

  • Concomitant use with Fenproporex can lead to hypertensive crises or serotonin syndrome due to increased norepinephrine and serotonin levels.


  • Fenproporex can antagonize the effects of antihypertensive drugs due to its sympathomimetic properties, which may increase blood pressure.

Other CNS Depressants:

  • Combining Diazepam with other central nervous system (CNS) depressants, such as opioids, sedative antihistamines, other benzodiazepines, barbiturates, and alcohol, can enhance CNS depressant effects. This can lead to increased sedation, respiratory depression, and, in severe cases, coma or death.

Oral Contraceptives:

  • Diazepam metabolism can be slowed down when taken concurrently with oral contraceptives, potentially leading to increased Diazepam levels in the blood.


  • The absorption rate of Diazepam might be slowed when taken with antacids, though the total absorption remains unchanged.

Cimetidine, Omeprazole, Fluvoxamine, and Fluoxetine:

  • These drugs can inhibit the metabolism of Diazepam, leading to increased blood levels and enhanced effects of Diazepam.

Phenytoin and Rifampicin:

  • These can increase the metabolism of Diazepam, possibly reducing its therapeutic effects.


  • Concurrent use can lead to a slowed metabolism of Diazepam, increasing its sedative effects.


  • Combining Diazepam with alcohol can lead to increased CNS depression. This can intensify sedation and can be life-threatening in terms of respiratory depression.

Appetite Suppressants or Stimulants:

  • Combining Fenproporex with other appetite suppressants or stimulants can enhance the sympathomimetic effects, leading to overstimulation, hypertension, and increased heart rate.


  • Fenproporex might reduce the antipsychotic effects of certain medications and lead to increased CNS stimulation.

It's crucial to remember that this is not an exhaustive list. Individuals should always discuss all medications, over-the-counter products, and dietary supplements they are taking with their healthcare provider to ensure they're aware of potential interactions. Monitoring and dosage adjustments may be required when combining Esbelcaps with other medications.
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