Geodon Ziprasidone

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Ziprasidone 40 mg belongs to the group of antipsychotic drugs, indole derivatives. The therapeutic effect is ensured by using Ziprasidone Hydrochloride Monohydrate as the active ingredient. Due to its affinity with dopamine and serotonin receptors, the drug is used to treat schizophrenia in adults.

Pharmacological features

A positron emission tomography study of the drug's efficacy was conducted to trace the effects on the receptors. Twelve hours after taking 40 mg of Ziprasidone, the blocking of type 2A serotonin receptors was increased by 80%. Blocking of D2 receptors was increased by more than 50%. The drug also acts on the 5HT2C, 5HT1D and 5HT1A receptors, and this action is greater than for the D2 receptors. It has weaker effects on the neuronal serotonin and norepinephrine transporters, histamine H(1)- and alpha(1)-receptors. It also has a weak effect on the muscarinic M(1) receptors.

The antipsychotic effect is due not only to the above effects, but also to the antagonistic effect on serotonin type 2A receptors (5HT2A) and dopamine type 2 receptors (D2). The effect on the nervous system is also caused by the antagonistic effect on the 5HT2C and 5HT1D receptors, the agonistic effect on the 5HT1A receptors and the inhibition of neuronal reuptake of noradrenaline and serotonin.

Pharmacokinetics action

Ziprasidone (Geodon) reaches maximum plasma concentrations 6-8 hours after administration. Efficacy and digestibility are increased when taking the drug simultaneously with food. Therefore, it's recommended to take the drug exactly with a meal. About 99% of the drug binds with the plasma proteins, which leads to effect on the body.

The elimination half-life is 6.6 hours on average. The excretion of the active substance from the body occurs in the following ratio: 20% in the urine and 60% in the feces. The drug is almost completely metabolized, and only less than 1% is excreted unchanged. During biotransformation, 4 active metabolites of benzisothiazol piperazine sulfoxide, benzisothiazol piperazine sulfone, ziprasidone sulfoxide and S-methylhydroziprazidone are formed.

Age and bad habits such as smoking have no effect on the action of Ziprasidone Geodon. Patients with impaired liver function have 30% higher blood concentrations than patients with a healthy liver.


Ziprasidone (Geodon) is prescribed for the treatment of schizophrenia in the form of tablets, but if oral administration is not enough, then the drug is used in the form of injections. In addition to schizophrenia, the drug has shown effectiveness in treating patients with bipolar disorder.


  • Allergy to the underlying component and excipients.
  • Congenital and established QT interval prolongation.
  • Abnormal functioning of the cardiovascular system: heart failure and myocardial infarction.
  • Treatment of arrhythmias with class 1 and class 3 antiarrhythmic agents.

Dosage of Ziprasidone

To get the effect of using the drug, 40 mg of Ziprasidone is prescribed twice a day. This dosage can be used as early as the third day of treatment. If there is no desired effect, you can increase the dose to 80 mg twice a day. A higher dose is not recommended because of the lack of data on the effect of the drug. The initial and maintenance dose is 20 mg twice a day. The recommended daily dose is reduced for patients with impaired liver function and if the patient is older than 65 years. No dose adjustment is required for patients with impaired renal function.

Interaction of Ziprasidone

The drug may potentiate the effects of antihypertensive drugs, so blood pressure should be monitored during such combinations. Ziprasidone Geodon may alter the pharmacokinetics of oral contraceptives, which also requires monitoring. Ketoconazole increases the blood concentration of an antipsychotic. With serotonergic agents, an adverse body reaction may occur.

Ziprasidone: weight gain

The drug may cause weight gain or loss, these phenomena are side effects with frequent occurrence. To avoid this happening before starting treatment, you need to undergo a comprehensive examination and not self-medicate.

Ziprasidone and alcohol

The drug cannot be combined with alcohol, but if the patient took a dose of alcohol before or after taking the drug, it's necessary to monitor the condition. In case of a negative reaction after such a combination, immediately take a sorbent and call your GP.

If a severe allergic reaction develops, an antiallergic drug must be injected immediately.

Ziprasidone for anxiety

The drug eliminates the negative reactions of the body caused by schizophrenia and bipolar disorder. Ziprasidone (Geodon) is prescribed to eliminate the symptoms of anxiety caused by these very diseases. To understand the cause of the anxiety, it is necessary to undergo an examination. If the anxiety is not caused by a mental disorder, the drug may not be effective.

Ziprasidone vs. Risperidone

Ziprasidone works better on dopamine, adrenergic, and serotonin receptors, but it lacks action on alpha2-adrenergic receptors, whereas risperidone has a 55.5 index of such action. Risperidone causes an increase in body weight to a greater extent. If with Zyprazidone this index is only 0.04 kg in 10 weeks, with risperidone this figure is 2.1 kg in 10 weeks. Only the treating physician can choose which drug will be effective in each individual case.

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  • Express USA time frame: 10-21 business days.   ($24.95 USD Signature required)
  • Express World Wide time frame: 15-30 business days.  ($39.95 USD Signature required)


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We offer Mex Post Express Shipping as an option. This option costs from $24.95 depending on the quantity of medications in your order (up to 9 medications). This option requires a customer signature on delivery. For all other locations Express Shipping is $39.95. All packages are shipped in plain packaging to guarantee your privacy. All packages are sent by parcel express mail from Mexico. Some parcels require a signature upon delivery at our discretion. There are no other handling fees, drug dispensing fees, or Mexican customs charges. If two or more people are ordering their prescription drugs from the same address at the same time, you will be billed for only one shipping charge from our Mexico pharmacy, up to our maximum order quantities limited by customs to 90 day supply. We are able to provide a tracking number on your express shipping parcels. If after 30 business days your order has not arrived, first check with your local postal office to ensure that your package is not being held for pick-up. If you still have problems, please contact us by email and we will attempt to assist you.

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Due to government regulations and the possibility of tampering with medications, returns cannot be accepted. In case your package is returned due to no one was available to sign for it. You can pay for reshipping $24.95 in order to receive a new tracking number. (Reshipping will be issued until the package is received back in our offices).

How to find the online pharmacy drug you need.
There are many more medications available in Mexico that are not listed on our website. If you can’t find the Mexican drug or medication you require, please contact us and we may be able to help. Some products are listed only in a single dosage size or medicine type, but may be available in other dosages and forms. Our experienced Mexican pharmacy Pharmacists will do their best to accommodate your requirements. Please always specify the chemical name of the medication (and any applicable brand name) with all inquiries. Please feel free to ask about ANY drug. We will reply promptly to your request.

What you should know about brand and generic drug alternates.
Prescription drugs are a costly medical expense, especially for the elderly, those who are chronically ill and those with no or minimal drug coverage on their Health Insurance. However, each state in America has a law that allows pharmacists to substitute less expensive generic drugs for many brand name products. Depending on your prescription needs, your savings could be very significant. Before you talk with your doctor or pharmacist about switching, there are things you should know about generic drugs.

What is the difference between a generic and brand name drug?
Nothing except for the name, packaging, and the price, a generic drug is called by its chemical name; manufacturers assign their own brand name. The generic products have the same ingredients. Standard practice and most state laws require that a generic drug be generically equivalent to its brand name counterpart. That is, it must have the same active ingredients, strength, and dosage form, be it a pill, liquid, or injection. The generic drug also must be therapeutically equivalent. It must be the same drug chemically and have the same medical effect.

Do all drugs have generic equivalents?
No. Some drugs are protected by patents and are supplied by only one company. However, when the patent expires, other manufacturers can produce its generic version. Currently, about half the drugs on the market are available in generic form.

Will my doctor automatically prescribe generic drugs?
It depends on the physician. You can ask your doctor to write a prescription permitting substitution of a generic drug product when appropriate or to define the chemical name for the prescription. This will ensure you are purchasing the correct Mexico drug. Generic products will be as effective and less costly. Or, you can order only brand name products if you wish. Mexico pharmacy offers a wide selection of both Brand Name & Generic Mexico medicine. Our Mexican generic drugs are of the highest quality, selected only from the most reputable manufacturers, and are safe to replace brand name medications costing much more.



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Geodon Ziprasidone
In stock


Geodon Ziprasidone