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Comprehensive Overview of Neobes (Amfepramone 75 mg) and Neobes Pills

Introduction: Neobes, commonly recognized by its generic name Amfepramone, is a medication primarily designed to promote weight loss in patients with obesity. It functions as an anorexigenic agent, which means it suppresses appetite, assisting those struggling with weight management.

Brand Information

Brand Name: Neobes

Generic Name: Amfepramone

Also Known As: Neobes pills

Formulation: Each Neobes tablet contains:

  • Active substance: Amfepramone 75 mg

When is Neobes Recommended? (Neobes Para Que Sirve)

For patients without associated diseases, Neobes is prescribed when the Body Mass Index (BMI) is 30 kg/m2 or more.

  • For those presenting risk factors, Neobes is considered suitable when the BMI is at least 27 kg/m2.

Dosage and Method of Administration

Amfepramone, the active ingredient in Neobes, is a part of comprehensive therapy for weight loss and maintenance. This therapy should encompass lifestyle modifications such as dietary adjustments and regular physical activity. Treatment duration with Neobes should be short-term, typically spanning several weeks.

The recommended dosing regimen for Neobes pills is:

  • Oral intake of 25 mg 2-3 times daily, preferably 30 minutes to an hour prior to main meals like breakfast and lunch.
  • If patients tolerate the medication well but find the effects insufficient, the daily dose might be adjusted to 0.1 g.
  • Typically, Neobes therapy lasts between 1.5 to 2.5 months. If there's a need for more treatment cycles, it's advised to take breaks of at least 3 months between them.

Potential Side Effects

Neobes pills may have some side effects, including:

  • Cardiovascular: Increased heart rate (tachycardia) and high blood pressure.
  • Central Nervous System: Symptoms like fatigue, headaches, insomnia, euphoria, mood swings, and irritability.
  • Digestive System: Dry mouth, nausea, bouts of vomiting, constipation, or diarrhea.
  • Allergic Responses: Manifestations like skin rash, itching, swelling of eyelids, rhinitis, and conjunctivitis.
  • Miscellaneous Effects: Muscle pain (myalgia), dysuria, increased urination (polyuria), hair loss (with prolonged use), decreased libido, and potential drug dependency.

It's vital to understand that Neobes Amfepramone carries a risk of addiction.


Interactions between medications can lead to altered efficacy, enhanced side effects, or unanticipated reactions. Here's an outline of potential interactions for Neobes containing Amfepramone Hydrochloride (also known by its alternate name, Norex):

Monoamine Oxidase Inhibitors (MAOIs):

  • Using Amfepramone alongside MAOIs can lead to hypertensive crises because of the increased levels of norepinephrine in the system.


  • Amfepramone can reduce the effects of antihypertensive medications due to its sympathomimetic properties, which can potentially elevate blood pressure.

Other CNS Stimulants:

  • Combining Amfepramone with other central nervous system stimulants can enhance the sympathetic effects, possibly leading to overstimulation, heightened blood pressure, and rapid heartbeat.

Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs):

  • There's a potential risk of developing serotonin syndrome, a life-threatening condition, when combining Amfepramone with these antidepressants.


  • Consuming alcohol while taking Amfepramone might amplify some of the side effects of the drug, like dizziness, impaired thinking, and risky behaviors.

Tricyclic Antidepressants:

  • The combination can increase the blood pressure and heart rate, risking potential hypertensive crises.

Over-the-counter Weight Loss Supplements:

  • Combining Amfepramone with OTC weight loss products, especially those containing stimulants or appetite suppressants, can amplify adverse reactions and the risk of heart and blood pressure issues.


  • Amfepramone might decrease the antipsychotic effects of certain medications and can lead to increased CNS stimulation.


  • Combining with medications like benzodiazepines can reduce the anorexigenic effect of Amfepramone, decreasing its efficacy in weight loss.


  • Beverages or supplements with caffeine can amplify the stimulant effect, leading to jitteriness, nervousness, palpitations, and potential increases in blood pressure.

It's crucial to remember that this is not a comprehensive list of interactions. Individuals should always consult their healthcare provider before combining Neobes with any other medication or supplement. It's essential to be aware of potential interactions and ensure regular monitoring when co-administering drugs with Neobes.

Overdose Management

In the event of an overdose, symptoms might include tremors, heightened reflexes, rapid breathing (tachypnea), confusion, hallucinations, circulatory collapse, and seizures (especially in those with epilepsy). Treatment measures involve inducing vomiting, stomach cleansing, diuresis enhancement, managing mental disorders with psychoactive medications, respiratory support if needed, and using beta-blockers for tachycardia.


Neobes should not be used by individuals with:

  • Atherosclerosis, high blood pressure, heart attacks, pheochromocytoma, pituitary tumors, diabetes, psychotic disorders, epilepsy, thyrotoxicosis, glaucoma, and children below 12.
  • Pregnant and breastfeeding women are also advised against the use of Neobes.

Expert Medical Advice

Always use Neobes under the guidance and close observation of a healthcare professional to ensure safety and efficacy.

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