The combined analgesic agent Tramacet (Paracetamolum + Tramadolum) for the somatic treatment of severe pain syndrome. Tramacet is a thickening medication for oral use.
In the practice of an outpatient doctor, pain is one of the most frequent pathological symptoms for which a patient seeks a doctor. Pain can be a manifestation of a wide variety of diseases, including those related to the areas of special sections of medicine (surgery, oncology, neurology, etc.).
Brand name: Tramacet
Generic name: Acetaminophen and Tramadol
Excipients: microcrystalline cellulose, pregelatinized starch, sodium starch glycolate, corn starch, purified water, magnesium stearate.
Medical advice: be sure to consult with a specialist before using the medication. Self-use can harm your health.
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Pharmaco-therapeutic group: analgesic agent with a mixed mechanism of action; analgesic non-narcotic agent.
Tramadol is an opioid synthetic analgesic, has an analgesic effect, is an agonist of opioid receptors. It has a central effect and action on the spinal cord (inhibits the conduct of pain impulses), enhances the effect of sedatives.
Paracetamol has analgesic and antipyretic effects. Blocks cyclooxygenase mainly in the central nervous system, affecting the centers of pain and thermoregulation. It does not irritate the gastrointestinal tract mucosa, does not affect water-salt metabolism.
Thus, both components of Tramacet have an inhibitory effect on different links in the conduction of pain impulses in the structures of the central nervous system, providing a synergistic analgesic effect. This synergy was the basis for determining the optimal ratio of reduced doses of tramadol and paracetamol acetaminophen when creating a finished combined dosage form: 37.5 / 325 mg.
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Always take this medication exactly as directed in the package insert, or as directed by your doctor or pharmacist. If you are unsure, check with your doctor or pharmacist.
For outpatient practice, acute and chronic severe pain syndromes of moderate intensity that are not relieved by simple non-opioid analgesics are most relevant, since they are especially common and cause difficulties for doctors in choosing an effective and affordable therapy. These include pain syndromes associated with diseases of the spine, joints, especially during periods of exacerbation, trauma, ambulatory invasive interventions.
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Unfortunately, even if there are indications for the use of the drug, it is not always used. You cannot use the drug if you are allergic (hypersensitive) to any of the ingredients or other benzodiazepines.
Before using Tramacet 37.5 mg tabs, familiarize yourself in detail with all possible contraindications:
- hypersensitivity to active or auxiliary components of the medicament;
- conditions accompanied by respiratory depression or severe depression of the central nervous system (including acute intoxication with alcohol or drugs, hypnotics, narcotic analgesics and psychotropic drugs);
- simultaneous administration of MAO inhibitors (and within 2 weeks after their cancellation);
- severe hepatic and / or renal failure (creatinine clearance less than 10 ml / min);
- epilepsy, uncontrolled by therapy;
- drug withdrawal symptoms;
- children up to age 14;
- pregnancy, lactation.
The drug Tramacet is prescribed with caution for the following diseases and conditions:
- traumatic brain injury, intracranial hypertension;
- a tendency to convulsive syndrome (in patients with therapeutically controlled epilepsy, the drug can only be used for health reasons);
- shock, confusion of consciousness of unknown etiology, impaired respiratory function;
- with the simultaneous use of psychotropic and other pain relievers of central action, local anesthesia;
- before general anesthesia;
- diseases of the biliary tract; benign hyperbilirubinemia, viral hepatitis, glucose-6-phosphate dehydrogenase deficiency;
- alcoholic liver damage, alcoholism, drug addiction;
- hepatic and renal (creatinine clearance less than 10-30 ml / min) failure of moderate severity;
- against the background of pain in the abdominal cavity of unknown origin ("acute abdomen");
- elderly patients (over 75 years old).
FDA Recommendations - Category C. Contraindicated in pregnancy and lactation.
Take your medication exactly as directed by your treating psychotherapist.
Do not take Tramacet or its analogues without a doctor's prescription, remember that self-medication can worsen your condition and harm your brain and overall health. The dosage regimen and duration of treatment are selected individually depending on the severity of the pain syndrome.
Inside, 1-2 tablets for pain, the interval in admission is at least 6 hours.
Highest daily dose: 8 tablets (2.6 paracetamol acetaminophen and 300 mg of tramadolum).
Higher single dose: 2 tablets.
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Acetaminophen: diarrhea, anorexia - with acute overdose (develops 6-14 hours after exceeding the dose), with chronic (develops 2-4 days after exceeding the dose) - hypocoagulation, disseminated intravascular coagulation syndrome, cerebral edema, rarely - fulminant renal failure due to tubular necrosis.
Tramadol hydrochloride: miosis, collapse, coma, convulsions, apnea.
Necrosis of liver cells due to the formation of a toxic metabolite of acetaminophen - N-acetyl-p-benzoquinone imine.
Treatment: the use of donors of SH-groups, precursors of the synthesis of glutathione - methionine and N-acetylcysteine within 12 hours after an overdose.
Introduction of naloxone, diazepam.
If you find any of the adverse reactions, discontinue treatment and immediately go to the hospital. In this case, the doctor is obliged to recommend another treatment.
Possible side reactions in patients.
System and organs
sulfhemoglobinemia, aplastic anemia, pancytopenia
The cardiovascular system
tachycardia, orthostatic hypotension, syncope
dry mouth, nausea, vomiting, flatulence, constipation, difficulty swallowing, diarrhea.
Central and peripheral nervous system
dizziness, headache, lethargy, nervousness, euphoria, hallucinations, tremors, muscle spasms, impaired cognitive function, gait instability, paresthesias, visual and taste disturbances
violation of the menstrual cycle
hyperhidrosis, bullous rash, toxic epidermal necrolysis (Lyell's syndrome)
The immune system
Check with your pharmacist for full information on adverse reactions.
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One in two or three people who develop cancer experience pain that is moderate to severe. The pain tends to get worse as the cancer progresses.
Monitoring of plasma glucose and uric acid, peripheral blood composition, liver functional state.
With prolonged use of the medicament, symptoms of drug dependence develop, with a sudden discontinuation of the drug - withdrawal syndrome.
During the period of treatment, alcohol is prohibited.
During treatment, driving a car and working with moving mechanisms is not recommended.
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Tramacet is a combination pain reliever consisting of 37.5 mg tramadol hydrochloride and 325 mg acetaminophen. The medicine is used to relieve severe pain syndromes, regardless of genesis.
Tramacet is more effective than tramadol. Paracetamol acetaminophen accelerates the onset of the analgesic effect, tramadol prolongs it. The combination of tramadol + paracetamol was more effective; the effect was faster and lasted longer than the component of the remedy alone.
El agente analgésico combinado Tramacet (Acetaminophen + Tramadolum) para el tratamiento somático del síndrome de dolor. Tramacet México es un analgésico oral. El medicamento se prescribe para los síndromes de dolor agudo y crónico de intensidad moderada que no pueden detenerse con analgésicos simples no opioides.
TRAMACET tablets are indicated for the symptomatic treatment of moderate to severe pain. Tramacet may also be used for purposes other than those listed in this medication guide. Please consult your physician before taking any medication.