Tramadol is a centrally-acting opioid analgesic that is used to treat the pain of various types and intensities.
Tramadol is commonly used as an analgesic and is used to treat persistent moderate to severe pain. The analgesic potency is comparable to that of morphine.
It is also suitable for the treatment of neuropathic pain, for pain relief for fibromyalgia, and for pain relief for toothaches and headaches.
In people with osteoarthritis, tramadol reduces the intra-articular concentration of Substance P and interleukin-6. This significantly reduces the pain caused by inflammation in the joint.
Tramadol is not an anti-inflammatory drug, it only relieves the pain of varying severity.
Tramadol is an opioid analgesic of central action. The active ingredient binds to μ-, δ-, and κ-opioid receptors. In addition, the active ingredient inhibits serotonin and norepinephrine reuptake.
Tramadol has analgesic and anti-cough effects, but does not have an inhibitory effect on respiration in a wide range of doses and does not affect the motility of the gastrointestinal tract.
More than 90 percent of Tramadol is absorbed after oral administration and has an absolute bioavailability of about 70 percent, regardless of food intake. The drug undergoes little first-pass metabolism, and about 20 percent binds to serum proteins.
Tramadol penetrates the blood-brain barrier and the placenta and is excreted with breast milk. The elimination half-life is about 6 hours regardless of administration.
Tramadol is mainly excreted via the kidneys, therefore a slight prolongation of the elimination half-life in hepatic and renal impairment should be expected.
Tramadol and Oxycodone are prescription painkillers you may be prescribed for moderate to severe pain when other treatments have not worked. Oxycodone and Tramadol interact with the brain's opioid receptors, reducing the transmission of pain signals. They can be used to treat different types of pain, including musculoskeletal pain and postoperative pain.
When Tramadol first appeared, it was not classified as a controlled substance. In 2014, the Drug Enforcement Administration (DEA) reclassified Tramadol as a Schedule IV controlled substance. Tramadol can be abused, and its use should be carefully monitored.
Oxycodone is a Schedule II controlled substance. It has a very high potential for addiction, abuse, and withdrawal.
Both medications must be taken every 4-6 hours, are not to have overdosed, and the duration of therapy should not be longer than 7 days.
Both drugs effectively eliminate pain, but each requires special care in their use.
The dosage of tramadol depends on the severity of the pain and the individual sensitivity of the patient.
For adults and adolescents over 12 years of age, the drug can be taken 50-100 mg as recommended by the physician to relieve pain every 4-6 hours, but not more than 400 mg/day. (except for long-acting drugs, they should be taken less frequently!).
Depending on the intensity of the pain, it is necessary to take the drug according to the doctor's instructions, without exceeding the maximum allowable amount.
Tramadol from Mexico reduces the severity of pain and photophobia associated with migraine headaches. It should be taken as directed or indicated by your doctor until the pain has gone away, but no more than 3 times a day.
The tablet or capsule containing Tramadol must be swallowed whole. It must not be broken, crumbled, or chewed. Also, the route of administration should not be changed; it should only be taken orally.
The most commonly reported side effects (≥10 percent of patients) are nausea and dizziness.
The following side effects may also occur frequently (≥1/100 to <1/10):
The possibility of side effects increases in elderly patients. The most common are dizziness, fainting, nausea, and vomiting.
One of the most common side effects of the drug is drowsiness.
Tramadol can cause constipation. If any side effects occur, it is necessary to consult a physician urgently; therapy may be corrected.
Tramadol should not be taken if there is: known hypersensitivity to tramadol, acute intoxication with alcohol, sleeping pills, analgesics, opioids and psychotropic agents, epilepsy, or substitution therapy.
If tramadol is to be used during pregnancy, it should be limited to single doses. Prolonged use should be avoided because tramadol penetrates the placenta and withdrawal symptoms may occur after birth in newborns.
Tramadol should not be used during breastfeeding. However, there is usually no need to stop breastfeeding after a single dose of tramadol.
Because tramadol use may cause drowsiness and dizziness, the ability to drive and operate machinery is impaired under these conditions.
The following interactions are possible when taking Tramadol:
Not all possible interactions are listed; our experienced pharmacists can advise you on this when ordering Tramadol online.
You cannot buy Tramadol without a prescription because this drug is sold only with a prescription.
But you can buy Tramadol online at an attractive price in our online pharmacy, with a free consultation from our specialists. Tramadol 50 mg price depends on the manufacturer and the quantity of the drug.